A team of Stanford neuroscientists may have stumbled onto a way to prevent the brain from aging–and if the results of tests on old mice are any indicator, the research is promising.
Hailed as a “stunning piece of research” by New Atlas, the study–published in peer-reviewed international journal Nature–managed to pinpoint a specific gene called CD22 that is responsible for cognitive loss resulting from aging. The gene, common to both mice and humans, apparently degrades certain cells’ ability to conduct normal brain activity.
That same gene was found to be three times more prevalent among older mice than younger ones in follow-on experiments.
With this data in mind, the researchers devised antibodies to block CD22–specifically, molecules that bind to proteins and can be generated in a lab.
The Stanford team then injected the antibodies into the hippocampus on one side of the brains of the test mice. After a month of injecting the CD22-blocking antibody into both sides of their brains, the mice that received the injection began outperforming their counterparts in various intelligence tests.
The researchers believe that this is because as we age, the microglia–the class of brain cells responsible for routine cleanup and immune responses–decline and lose their ability to engage in the sort of “maintenance” work that brains require.
In a statement, study author and professor of neurology and neurological sciences Tony Wyss-Coray said:
“The mice became smarter … Blocking CD22 on their microglia restored their cognitive function to the level of younger mice. CD22 is a new target we think can be exploited for treatment of neurodegenerative diseases.”
This research could open the path to reverse a range of cognitive effects of aging–including such diseases as Parkinson’s and Alzheimer’s.
“Many of the genes whose high-risk variants have recently been linked to Alzheimer’s disease are known to be active in the brain only in microglia … Microglial genes’ activation patterns are abnormal in Alzheimer’s patients, and in other neurodegenerative disorders including Parkinson’s disease and amyotrophic lateral sclerosis.”
Yet the new research could be promising, especially when–or if–it eventually reaches human trials. The Stanford team remains optimistic, with Wyss-Coray noting:
“We think we may have discovered a way to get these cells back on track and make them work the way they used to when we were young.”
Dolphin Swims Through Louisiana Neighborhood in Aftermath of Hurricane Ida
A Louisiana family was shocked to find a dolphin swimming through their neighborhood in the aftermath of Hurricane Ida.
Amanda Huling and her family were assessing the damage to their neighborhood in Slidell, Louisiana, when they noticed the dolphin swimming through the inundated suburban landscape.
In video shot by Huling, the marine mammal’s dorsal fin can be seen emerging from the water.
“The dolphin was still there as of last night but I am in contact with an organization who is going to be rescuing it within the next few days if it is still there,” Huling told FOX 35.
Ida slammed into the coast of Louisiana this past weekend. The Category 4 hurricane ravaged the power grid of the region, plunging residents of New Orleans and upwards of 1 million homes and businesses in Louisiana and Mississippi into the dark for an indefinite period of time.
Officials have warned that the damage has been so extensive that it could take weeks to repair the power grid, reports Associated Press.
Also in Slidell, a 71-year-old man was attacked by an alligator over the weekend while he was in his flooded shed. The man went missing and is assumed dead, reports WDSU.
Internet users began growing weary last year about the steady stream of stories belonging to a “nature is healing” genre, as people stayed indoors and stories emerged about animals taking back their environs be it in the sea or in our suburbs.
However, these latest events are the surreal realities of a world in which extreme weather events are fast becoming the new normal – disrupting our lives in sometimes predictable, and occasionally shocking and surreal, ways.
Mom in LA Suburbs Fights Off Mountain Lion With Bare Hands, Rescues 5-Year-Old Son
A mother in Southern California is being hailed as a hero after rescuing her five-year-old son from an attacking mountain lion.
The little boy was playing outside his home in Calabasas, a city lying west of Los Angeles in the Santa Monica Mountains, when the large cat pounced on him.
The 65-pound (30 kg) mountain lion dragged the boy about 45 yards across the front lawn before the mother acted fast, running out and striking the creature with her bare hands and forcing it to free her son.
“The true hero of this story is his mom because she absolutely saved her son’s life,” California Department of Fish and Wildlife spokesman Captain Patrick Foy told Associated Press on Saturday.
“She ran out of the house and started punching and striking the mountain lion with her bare hands and got him off her son,” Foy added.
The boy sustained significant injuries to his head, neck and upper torso, but is now in stable condition at a hospital in Los Angeles, according to authorities.
The mountain lion was later located and killed by an officer with the California Department of Fish and Wildlife, who found the big cat crouching in the bushes with its “ears back and hissing” at the officer shortly after he arrived at the property.
“Due to its behavior and proximity to the attack, the warden believed it was likely the attacking lion and to protect public safety shot and killed it on sight,” the wildlife department noted in its statement.
The mountain lion attack is the first such attack on a human in Los Angeles County since 1995, according to Fish and Wildlife.
The Santa Monica Mountains is a biodiverse region teeming with wildlife such as large raptors, mountain lions, bears, coyote, deer, lizards, and snakes. However, their numbers have rapidly faded in recent years, causing local wildlife authorities to find new ways to manage the region’s endemic species.
Video Shows Taliban Taking Joyride in Captured US Blackhawk Helicopter
The rapid fall of Kabul to the Taliban has resulted in a number of surreal sights – from footage of the Islamist group’s fighters exercising at a presidential gym to clips of combatants having a great time on bumper cars at the local fun park.
However, a new video of Taliban members seemingly testing their skills in the cockpit of a commandeered UH-60 Black Hawk helicopter shows the chilling extent to which U.S. wares have fallen into the hands of a group it spent trillions of dollars, and exhaustive resources, to stamp out.
In the new video, shared on Twitter, the front-line utility helicopter can be seen taxiing on the ground at Kandahar Airport in southeastern Afghanistan, moving along the tarmac. It is unclear who exactly was sitting in the cockpit, and the Black Hawk cannot be seen taking off or flying.
It is unlikely that the Taliban have any combatants who are sufficiently trained to fly a UH-60 Black Hawk.
The helicopter, which carries a $6 million price tag, is just a small part of the massive haul that fell into the militant group’s hands after the country’s central government seemingly evaporated on Aug. 14 amid the withdrawal of U.S. and coalition troops.
Some 200,000 firearms, 20,000 Humvees and hundreds of aircraft financed by Washington for the now-defunct Afghan Army are believed to be in the possession of the Taliban.
The firearms include M24 sniper rifles, M18 assault weapons, anti-tank missiles, automatic grenade launchers, rocket-propelled grenades and mortars.
Taliban fighters in the elite Badri 313 Brigade have been seen in propaganda images showing off in uniforms and wielding weaponry meant for the special forces units of the Afghan Army.
The U.S. is known to have purchased 42,000 light tactical vehicles, 9,000 medium tactical vehicles and over 22,000 Humvees between 2003 and 2016.
The White House remains unclear on how much weaponry has fallen into Taliban hands, with National Security Adviser Jake Sullivan admitting last week that the U.S. lacks a “clear picture of just how much missing $83 billion of military inventory” the group has.