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Scientists Cleared Alzheimer’s Plaque From Mice Using Nothing but Light and Sound

Strobe lights and a low pitched buzz can be used to recreate brain waves lost in the disease.

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Alzheimer's
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(TMU) — In previous articles, we discussed the importance of brain waves in modern technological developments. It even seemed like something “magical” to me, when I was writing about how through brain waves and AI scientists can “see” what you are seeing in real-time. Now, even more progress is being made thanks to neuroscientists at MIT.

So far, there is no cure for Alzheimer’s despite rapid growth in the number of people living with the disease. It is estimated that around 44 million people around the world suffer from this condition or a related form of dementia. In the U.S., an estimated 5.5 million people have Alzheimer’s disease. It is also the sixth-leading cause of death in the U.S, killing even more people than breast and prostate cancer combined.

Even though a few drugs temporarily manage certain cognitive symptoms of the illness, none of them can stop Alzheimer’s progression. Virtually all new treatments have failed in clinical trials. “We really don’t have much to offer people,” says Shannon Macauley, a neuroscientist at Wake Forest School of Medicine.

This new research basically works with imitating the healthy rhythmic patterns—or brain waves—that operate at different frequencies. Gamma brain waves oscillate at roughly 30 to 100 Hz and are associated with higher-order cognitive functions, and they are also known to decrease in the brains of people suffering from Alzheimer’s.

A previous study showed that flashing light 40 times a second into the eyes of mice treated their Alzheimer’s disease. If this was not amazing enough, researchers also added sound of a similar frequency and this dramatically improved the results. In a way, we can be talking of “healing frequencies”… some “alternative” therapies in medicine may not sound so crazy now, huh?

This noninvasive treatment also greatly reduced the number of amyloid plaques found in the brains of these mice. Plaques were cleared in large swaths of the brain, including areas critical for cognitive functions such as learning and memory.

“When we combine visual and auditory stimulation for a week, we see the engagement of the prefrontal cortex and a very dramatic reduction of amyloid,” said Li-Huei Tsai, one of the researchers from MIT’s Picower Institute for Learning and Memory.

Another fact to consider is that the researchers found that if they treated the mice for one week, then waited another week to perform the tests, many of the positive effects had faded, suggesting that the treatment would need to be given continuously to maintain the benefits.

Tsui used a frequency ranging around 40 Hertz, a sound only just high enough for humans to hear, and as a “side effect,” it also helped clear the nearby hippocampus, an important area of the brain associated with memory. After treatment, mice exposed to this “therapy” performed better in a range of cognitive tasks. Findings show an overall neuroprotective effect, even in the later stages of neurodegeneration, the researchers reported.

“Though there are important differences among species, there is reason to be optimistic that these methods can provide useful interventions for humans,” says Nancy Kopell, a professor of mathematics and statistics at Boston University.

While further research is needed and a few numbers to understand, such as 40, the frequency that is creating a profound impact in mice, this is encouraging news to finally have an effective treatment for all stages of Alzheimer’s disease.

By Manuel García Aguilar  | Creative Commons | TheMindUnleashed.com

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Adam Toledo: Chicago Police Video Shows 13-Year-Old’s Hands Were Up When Cops Shot Him

Elias Marat

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The Chicago Police Department has released gruesome footage depicting the moment that police officers fatally shot 13-year-old Adam Toledo while his hands were up.

In new bodycam footage from the March 29 slaying, an officer pursuing Toledo can be heard shouting at the young boy to show his “f*cking hands” before shooting him a single time, leaving the boy covered in blood and gasping for air.

While the officer can be heard shouting “drop it,” the teenager appeared to have empty hands when he raised his arms in the moment before he was shot. Video also shows officers discovering a handgun near the scene.

Adam was later pronounced dead at the scene.

The video released Thursday by the Civilian Office of Police Accountability the footage from the officer who shot Toledo, along with 16 other body-warn camera video clips, two recordings of 911 calls, an incident report, and a response report, along with other materials.

The mother of Adam, Elizabeth Toledo, reported the boy one week prior to the shooting, although he did return hom on March 27 before leaving that night, reports WBEZ.  Because Adam did not have any form of identification, the family wasn’t informed by police about his death until March 31. In a GoFundMe page set up by Elizabeth, it was noted that one of Adam’s “dreams was to become a police officer.”

“It weighs heavy on our hearts to be planning our last goodbyes instead of watching him grow up and live out those dreams,” the family noted on the page.

The child has been described as having a “big imagination” and was a fan of children’s shows and zombie movies.

“Adam was really into zombies. And the zombie apocalypse. He even had this zombie apocalypse bag packed and ready to go. Some of his favorite movies and TV shows were ‘Cloudy with a Chance of Meatballs,’ ‘Ghostbusters,’ ‘SpongeBob SquarePants,’ ‘Toy Story,’ ‘Cars,’ ‘The Walking Dead,’” Elizabeth told the Chicago Sun-Times.

Chicago Mayor Lori Lightfoot has appealed for calm over the release of the gruesome footage while businesses in the area have boarded up their windows in anticipation of large protests.

“We live in a city that is traumatized by a long history of police violence and misconduct,” the mayor told reporters. “So while we don’t have enough information to be the judge and jury of this particular situation, it is certainly understandable why so many of our residents are feeling that all too familiar surge of outrage and pain.”

The release of the video comes amid continuing anger and grief over the April 11 shooting of Daunte Wright by an officer in a Minneapolis suburb.

It also comes as authorities fear a new wave of protests as communities await the outcome of the trial of Derek Chauvin, the former Minneapolis Police officer accused of killing George Floyd last May after kneeling on his neck for 9 minutes and 29 seconds.

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Music

Lil Nas X Song Is #1 In Saudi Arabia, Where Homosexuality Is Illegal Under Sharia Law

Elias Marat

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Lil Nas X has been on top of the world for weeks now, whether it’s living rent-free in the heads of homophobes or topping the Billboard charts after his smash hit “Montero (Call Me By Your Name)” dominated playlists.

And ironically, the anthem has become the most-played song in Saudi Arabia, the conservative kingdom where open expressions of same-sex love and even private acts of gay sex are punishable by death.

The song, whose video features the artist giving Satan himself a lap dance have dominated news conversations all over the globe, smashed through to the top of the Billboard Global 200, which ranks top tracks in over 200 territories, on Monday.

According to Apple Music, the song is also leading Saudi Arabia’s top 100 charts as the most-played song in the country.

Apparently overjoyed by the ranking, Lil Nas X tweeted: “WE NUMBER 1 IN SAUDI ARABIA WTF LETS GOOOO”

The autocratic kingdom, which has long been governed by a strict yet uncodified interpretation of Sharia law, has an atrocious record on LGBTQ rights and classifies homosexuality as a variety of extremism. N many circumstances, gay sex is punishable by death.

As the Human Dignity Trust explains, “The punishment varies depending on the circumstances: married men and interfaith sex are punished with the death penalty, while non-married men are punished with flogging. Sharia law principles underpinning the criminal law in Saudi Arabia also impose strict dress codes that impact on the gender expression of transgender people.”

However, this does not mean that Saudi citizens abstain from these “illicit” acts. As one fan wrote on Twitter: Period!!!! Let’s correct the narrative about the Middle East! Shoutout Saudi Arabia.”

However, another user responded: “I lived in Saudi Arabia my whole [life] and if I come out I will literally get stoned and people will be happy about it, saying it’s a ‘narrative’ doesn’t help anyone in the contrary, the middle IS homophobic and change NEEDS to happen.”

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Corruption

Cop Who ‘Accidentally’ Killed Daunte Wright Arrested on 2nd-Degree Manslaughter Charges

Elias Marat

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The former Minnesota cop who shot and killed Daunte Wright, a 20-year-old unarmed Black man, during a traffic stop will now face charges of second-degree manslaughter, a prosecutor announced on Wednesday.

The brutal killing of Wright, which comes amid the trial of former Minneapolis police officer Derek Chauvin for last May’s killing of George Floyd, threatens to spark a new round of nationwide protests against police brutality and discriminatory policing.

On Wednesday, Washington County Attorney Pete Orput confirmed that Potter, a 26-year veteran of the Brooklyn Center Police Department, would be charged.

On Wednesday morning, agents with the Minnesota Bureau of Criminal Apprehension arrested Potter, the bureau announced in a statement.

Potter was taken into custody in St. Paul and will be booked at Hennepin County jail.

On Tuesday, Potter resigned as demands for justice for Wright reverberated nationwide. Her resignation coincided with that of the city’s former police chief, who claims that Potter accidentally grabbed her Glock when she thought she was reaching for her Taser during the Sunday traffic stop.

Wright’s family and attorneys have rejected the claim that Wright’s death was merely the result of an “accident” and are demanding accountability and sweeping reforms of policing in Minnesota.

Potter could face up to 10 years in prison along with a $20,000 fine, per Minnesota law.

“While we appreciate that the district attorney is pursuing justice for Daunte, no conviction can give the Wright family their loved one back,” said Wright family attorney Ben Crump in a statement.

“This was no accident. This was an intentional, deliberate and unlawful use of force,” the statement added.

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