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New Study Suggests Binge Drinking Could Damage Brain And Cause Lasting Anxiety

A study suggests that binge drinking alcohol could seriously damage the brain in ways that increase the risk of cognitive-behavioral issues like anxiety.

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(TMU) – A recent study suggests that binge drinking alcohol could seriously damage the brain in ways that increase the risk of cognitive-behavioral issues like anxiety.

The study, which was conducted by researchers at the University of Porto, found that just ten days of binge drinking cause immune cells in the brain to destroy connections between neurons, which leads to anxiety and other mental health issues.

It is important to note that these were not human studies, as the test subjects were mice, but these types of experiments typically give significant insight into how different substances affect the brains of humans.

Study co-author João Relvas, told Inverse that, [We] don’t have any reason to believe that the same mechanisms will not be operating in the human brain. Even for a short period of time, excessive drinking is likely to affect the brain, increasing the level of anxiety, a relevant feature in alcohol abuse and addiction.”

“The dangers of alcohol drinking, especially amongst the younger population, have been widely underestimated and excessive alcohol drinking is socially relatively well tolerated. Increasing public awareness and education of the young can, together with other measures, change the way society looks at alcohol intake,” Relvas added.

In the study, the researchers broke the mice off into two groups. One group was given alcohol over a 10 day time period, while the other group was not. Half of the mice were given 1.5 grams per kilogram of ethyl alcohol each day, which is the equivalent of five drinks for an adult human that weighs 165 pounds.

After 10 days, the researchers looked at the mice’s brain tissue and found that the mice who consumed alcohol had significant damage to the area of the brain that controls complex cognition and decision making, which resulted in increased anxiety.

The researchers also determined the process that caused this damage in the brain. They believe that alcohol boosts the production of an inflammatory molecule called TNF.

In further experiments, they used a drug called pomalidomide to block TNF and found that it prevented anxiety and reduced the impact that the alcohol had on the brain.

The symptoms are “ultimately driven by increased secretion of TNF by microglia, as we show that reducing its production either pharmacologically or genetically can prevent synapse loss and anxiety,” Relvas says.

Relvas also said that this drug could potentially be used to treat alcohol addiction.

“This study suggests that regulating the levels of TNF might eventually be useful when treating alcohol addiction,” he said.

However, the team does not recommend that anyone use TNF inhibitors while binge drinking, because further studies need to be done to confirm the safety and efficacy of the drugs for the purpose.

Furthermore, TNF inhibitors would not prevent any of the other damage that alcohol can do to the rest of the body.

“Alcohol abuse is a leading cause of disease with a massive impact on human life and should be treated as so,” Relvas says.

His team’s findings were published earlier this month in the journal Science Signaling.

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Betty White Turns 99, and Her Tips on Living a Long and Happy Life Are More Valuable Than Ever

Elias Marat

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Betty White, the original golden girl beloved by people of all ages, celebrated her 99th birthday on Sunday.

The spry granny, born Betty Marion White on Jan. 17, 1922, has managed to live a long, healthy, happy life and this can likely be chalked up to her unconventional approach.

The Emmy award-winning veteran actress once joked that her secret to longevity consisted of three simple ingredients: vodka, hot dogs, and her love of pets.

However, her tongue-in-cheek advice is getting new attention, especially given that too many of us have been forced to stay at home over much of the past year.

In 2011, during a Late Show interview with David Letterman, White gave 10 sagely tips on how she’s managed to maintain her verb and energy for so long. With White reaching one year short of a century, the advice is worth revisiting.

Her first bit of advice was to “get at least eight hours of beauty sleep, nine if you’re ugly.” Next, she advised that one should “Exercise. Or don’t. What the hell do I care?”

Third, she opined that one should “never apologize. It shows weakness.”

Her fourth tip shouldn’t give anyone any adventurous ideas, but it’s helpful nonetheless: “The best way to earn a quick buck is a slip and fall lawsuit.”

She then gave the priceless tip that one should “avoid tweeting any photos of your private parts” while also making sure to “schedule nightly appointment with Dr. Johnnie Walker.”

Some of the healthy eaters in our audience may take exception to White’s seventh tip, which is to: “Take some wheatgrass, soy paste and carob, toss it in the garbage and cook yourself a big-*ss piece of pork.”

Her next bit of adice was to “try not to die” and “never dwell on past mistakes,” which may both be easier said than done. Lastly, she recommended that you “don’t waste your time watching this crap.”

Sound advice that we can all relate to, Mrs. White!

White is reportedly spending her 99th birthday simply relaxing, she told Entertainment Tonight.

“You probably didn’t ask, but I’ll tell you anyway. … What am I doing for my birthday? Running a mile each morning has been curtailed by [coronavirus], so I am working on getting ‘The Pet Set’ re-released, and feeding the two ducks who come to visit me every day,” she explained, referencing a 1971 show she starred in that featured celebrities appearing alongside their pets.

Her birthday was also marked by various celebrities, who tweeted out birthday greetings to the TV icon.

“Happy birthday, @BettyMWhite! You’re a miracle in every way,”  wrote Ellen DeGeneres.

“I still get warm when I see this look. Happy 99 baby. You are a testament to living life on your own terms. Sending you a great big socially distanced kiss. I love you @BettyMWhite,” Ed Asner tweeted.

“Betty White bloopers are the best bloopers #HappyBirthdayBettyWhite,” Valerie Bertinelli tweeted alongside a video of hilarious mistakes made on the set of their former show, Hot in Cleveland.

“Wishing the incomparable Betty White a very happy 99th birthday! What’s your favorite Betty White role, friends?” wrote Star Trek star George Takei.

White, who is best known for her role as Rose Nylund in the classic sitcom The Golden Girls (1985-92), has over 75 years in show business under her belt. The comedian became a staple of U.S. television in such shows as The Mary Tyler Moore Show and Hot in Cleveland along with memorable appearances in shows like Mama’s Family and That ‘70s Show.

She catapulted to fame with her first sitcom, Life with Elizabeth, where White played the titular role and became the first woman to have creative control of a program as both a producer and the star.

White earned no less than 24 Emmy nominations and won eight in the span of her career.

When she reached the age of 90 it didn’t slow her down one bit. Not only did White become the oldest host in the history of Saturday Night Live but she also made dozens of cameos. White also starred in a memorable 2010 Super Bowl commercial for Snickers where she got tackled to the ground, football-style.

In an email to the Associated Press, White shared an especially enjoyable perk of old age: “Since I am turning 99, I can stay up as late as I want without asking permission!”

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Environment

Mexico Decrees Ban on GMO Corn and Monsanto’s Glyphosate Weed Killer

Elias Marat

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Mexico’s President Andres Manuel Lopez Obrador has rung in the New Year by decreeing an end to the use of glyphosate – best known as the active ingredient in Monsanto’s “Roundup” pesticides – and also ordering the phase-out out of genetically modified corn for use in the food industry, with both goals to be realized by January 2024.

The move has been widely hailed by organic food producers and environmental, health, and social justice advocates, who welcome the move as crucial to preserve Mexico’s native corn crops, national heritage, and food sovereignty from the threat of multinational food corporations.

On Thursday, the government published an official decree stating that federal biosecurity authorities would “revoke and refrain from granting permits for the release of genetically modified corn seeds into the environment,” reports Reforma news agency.

The decree noted that the object of the decision, which came after months of unsuccessful pushback from lobbyist groups representing the massive food industry, was to “contribute to food security and sovereignty” and protect “native corn, cornfields, bio-cultural wealth, farming communities, gastronomic heritage and the health of Mexicans.”

The move makes good on promises by President Lopez Obrador, popularly known by his initials AMLO, to preserve native corn varieties from the threat of GMO corn.

The government of Mexico has taken numerous steps in recent months to safeguard the over 60 types of corn developed with traditional and indigenous agricultural methods that are, by law, considered a part of Mexico’s national food and cultural heritage.

Indigenous peoples in the Mesoamerican region cultivated the first strains of corn thousands of years ago, but multinational corporations have been flooding the Mexican market with varieties of corn that have been genetically modified to resist certain types of infestations and adverse climate conditions such as drought.

The government also ordered the phase-out of GMO corn imports for use in the food industry and decreed the elimination of the chemical glyphosate – the active ingredient in Bayer-Monsanto’s weedkiller, Roundup.

While a total ban on glyphosate isn’t yet possible in Mexico – especially amid major pushback from Big Ag lobbyists – federal agencies must immediately halt “purchasing, using, distributing, promoting and importing glyphosate or agrochemicals that contain it as an active ingredient,” according to the decree.

Instead, they must use “culturally appropriate” alternatives such as low-toxicity agrochemicals and organic products.

Opponents of the use of genetically modified crops have hailed the ban.

“It’s a great victory,” said Homero Blas, the director of the Mexican Society of Organic Producers. His group, like many other civil society organizations, blames GMO crops for contaminating the native, ancient varieties of corn while saying that the widespread use of dangerous pesticides endangers the health of both producers and consumers while undermining biodiversity.

However, GMO advocates such as the National Agricultural Council (CAN) claim that the prohibition of GMO corn cultivation will harm farmers while curbing imports will harm the Mexican food chain.

“The lack of access to production options puts us at a disadvantage compared to our competitors, such as corn farmers in the United States,” said CNA spokeswoman Laura Tamayo, who is also the regional director for the German multinational Bayer AG, the parent company to agro-chemical subsidiary Monsanto.

Glyphosate has been at the center of safety concerns in numerous countries and has also been the focus of massive lawsuits in the U.S. in recent years over the allegedly carcinogenic effects of the herbicide Roundup, which Monsanto introduced in 1974.

In July, Bayer agreed to pay as much as $10.9 billion to settle nearly 100,000 lawsuits in the U.S. claiming that the chemical causes a type of blood cancer.

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Health

CDC Study: Brain-Eating Amoeba Is Spreading in United States

Justin MacLachlan

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According to a new study by researchers from the Centers for Disease Control and Prevention (CDC), Naegleria fowleri, or the “brain-eating amoeba,” is spreading into the U.S. and scientists blame climate change.

Where as the actual number of yearly cases isn’t increasing the cases are occurring in a larger range of the U.S. than before. The the CDC study published in the journal Emerging Infectious Diseases this week, examined CDC data from 1978 to 2018, finding that new cases moved northwards at about 8.2 miles per year.

Since the amoeba prefers warm waters, up to what Live Science reports to be a hot-tub-like 113 degrees Fahrenheit, an upward shift in global temperatures caused by climate change is giving N. fowleri new opportunities to expand north over the last 40 years, according to the CDC study.

“It is possible that rising temperatures and consequent increases in recreational water use, such as swimming and water sports, could contribute to the changing epidemiology of PAM,” the paper reads.

Naegleria fowleri is a free-living amoeba that causes primary amebic meningoencephalitis (PAM), a disease of the central nervous system. Naegleria fowleri infections are extremely rare in the U.S. but the contagion is almost always fatal. In the United States, there have only been 145 PAM infections from 1962 through 2018 with only four survivors according to the CDC. If humans accidentally drink the microbe, it’s harmless. But if it makes its way inside the nose it’s usually lethal.

Naegleria fowleri occurs naturally in freshwater, the soil, warm lakes, rivers, and hot springs. It usually infects people when contaminated water enters the body through the nose and then travels to the brain.

The Centers for Disease Control and Prevention (CDC) says infection typically happens when somebody go swimming or diving in “warm freshwater places”.

The CDC says people cannot get infected by swallowing contaminated water, and it cannot be passed from person to person.

Those infected with Naegleria fowleri have flu-like symptoms including fever, nausea, and vomiting. Besides the normal symptoms showing someone is sick Naegleria fowleri comes with a stiff neck and headaches. Most people infected do not recover and usually die within just a week after the amoeba is within their brain.

Since the amoeba prefers warm waters, up to what Live Science reports to be a hot-tub-like 113 degrees Fahrenheit, an upward shift in global temperatures caused by climate change is giving N. fowleri new opportunities to expand north over the last 40 years, according to the CDC study published in the journal Emerging Infectious Diseases this week.

Earlier this year, eight Texas cities warned their residents about the tap water system after the deadly brain-eating amoeba was found in the public water supply. A Do Not Use Water Advisory was issued for the residents as well with at least one death of a little boy which sparked the investigation.

Additionally this year there was also an infection of Naegleria fowleri that was confirmed in the U.S. state of Florida. At the time, health officials there urged locals to avoid nasal contact with water from taps and other sources. Two children in Minnesota died from N. fowleri in 2010 and 2012 — both cases “550 miles north of the previously reported northernmost case in the Americas.”

The amoeba was found to be thriving in U.S. rivers and lakes more and more, earlier this year. Insider reports that cases may increase as climate change warms waters. Experts estimate that between 3 and 8 Americans die from N. fowleri annually.

Furthermore, there have only been 34 infections reported in the U.S. in the last ten years, according to CDC data.

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